Micro-CT imaging of Randall’s plaques

Noninvasive Imaging of Atherosclerotic Plaques Using MRI and CT

Noninvasive, high-resolution MRI has shown its efficacy in the visualization of carotid atherosclerotic plaque characteristics. MRI is the only noninvasive option for thin plaque cap, active inflammation, fissured/injured plaque and intraplaque hemorrhage, is also useful in monitoring the response after statin therapy, and has the potential to image a coronary plaque and to determine its compos...

High-resolution CT imaging of carotid artery atherosclerotic plaques.

BACKGROUND AND PURPOSE Plaque morphologic features have been suggested as a complement to luminal narrowing measurements for assessing the risk of stroke associated with carotid atherosclerotic disease, giving rise to the concept of "vulnerable plaque." The purpose of this study was to evaluate the ability of multidetector-row CT angiography (CTA) to assess the composition and characteristics o...

Temporal and spectral imaging with micro-CT.

PURPOSE Micro-CT is widely used for small animal imaging in preclinical studies of cardiopulmonary disease, but further development is needed to improve spatial resolution, temporal resolution, and material contrast. We present a technique for visualizing the changing distribution of iodine in the cardiac cycle with dual source micro-CT. METHODS The approach entails a retrospectively gated du...

Correlating Micro-CT Imaging with Quantitative Histology

Novel CT-based imaging markers for high-risk coronary plaques.

A large proportion of patients with suspected coronary artery disease who are referred for coronary computed tomography angiography (CTA) have coronary atherosclerotic lesions that do not cause significant anatomical luminal obstruction. These nonobstructive coronary artery lesions provide incremental prognostic information over the presence of obstructive lesions and clinical variables. 5 Howe...